Frequency, timing, and type of prodromal symptoms associated with hereditary angioedema attacks

According to a study recently published in Allergy and Asthma Proceedings, 87.0% of HAE patients report the presence of prodromal symptoms before their last HAE attack and 95.7% pf them reported having had prodromal symptoms before HAE attacks in the past. The most commonly reported prodromal symptoms included unusual fatigue, rash, and muscle aches. Prodromes occur frequently before HAE attacks. This high frequency suggests that prodromal symptoms could be a reliable indication to begin treatment to prevent an acute HAE attack, thus decreasing the anxiety associated with having an HAE attack.

Source: PMID: 19843405. Allergy Asthma Proc. 2009 Sep-Oct;30(5):506-11.
Last update: 10.25.2009.